A comparison of four liquid chromatography-mass spectrometry platforms for the analysis of zeranols in urine.

ABSTRACT: Targeted biomonitoring studies quantifying the concentration of zeranols in biological matrices have focused on liquid chromatography interfaced to mass spectrometry (LC-MS). The MS platform for measurement, quadrupole, time-of-flight (ToF), ion trap, etc., is often chosen based on either sensitivity or selectivity. An instrument performance comparison of the benefits and limitations using matrix-matched standards containing 6 zeranols on 4 MS instruments, 2 low-resolution (linear ion traps), and 2 high-resolution (Orbitrap and ToF) was undertaken to identify the best measurement platform for multiple biomonitoring projects characterizing the endocrine disruptive properties of zeranols. Analytical figures of merit were calculated for each analyte to compare instrument performance across pl

SUBMITTER: Lazofsky A 

PROVIDER: S-EPMC10386926 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature