The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis.

ABSTRACT:

Background and objective

The impact of liver cirrhosis on the activity of UDP-glucuronosyltransferases (UGTs) is currently not well characterized. We investigated the glucuronidation capacity and glucuronide accumulation in patients with liver cirrhosis.

Methods

We administered the Basel phenotyping cocktail (caffeine, efavirenz, flurbiprofen, omeprazole, metoprolol, midazolam) to patients with liver cirrhosis (n = 16 Child A, n = 15 Child B, n = 5 Child C) and n = 12 control subjects and obtained pharmacokinetic profiles of substrates and primary metabolites and their glucuronides.

Results

Caffeine and its metabolite paraxanthine were only slightly glucuronidated. The metabolic ratio (AUC_glucuronide/AUC_parent, MR) was not affected for caffeine b

SUBMITTER: Duthaler U 

PROVIDER: S-EPMC10386950 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature