Dataset Information

Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial.

ABSTRACT: We present data from the Heart Rate Variability and Emotion Regulation (HRV-ER) randomized clinical trial testing effects of HRV biofeedback. Younger (N = 121) and older (N = 72) participants completed baseline magnetic resonance imaging (MRI) including T₁-weighted, resting and emotion regulation task functional MRI (fMRI), pulsed continuous arterial spin labeling (PCASL), and proton magnetic resonance spectroscopy (¹H MRS). During fMRI scans, physiological measures (blood pressure, pulse, respiration, and end-tidal CO₂) were continuously acquired. Participants were randomized to either increase heart rate oscillations or decrease heart rate oscillations during daily sessions. After 5 weeks of HRV biofeedback, they repeated the baseline measurements in addition to new measures (ultimatum game fMRI, training mimicking during blood oxygen level dependent (BOLD) and PCASL fMRI). Participants also wore a wristband sensor to estimate sleep time. Psychological assessment comprised three cognitive tests and ten questionnaires related to emotional well-being. A subset (N = 104) provided plasma samples pre- and post-intervention that were assayed for amyloid and tau. Data is publicly available via the OpenNeuro data sharing platform.

SUBMITTER: Yoo HJ

PROVIDER: S-EPMC10387077 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial.

Yoo Hyun Joo HJ Nashiro Kaoru K Min Jungwon J Cho Christine C Mercer Noah N Bachman Shelby L SL Nasseri Padideh P Dutt Shubir S Porat Shai S Choi Paul P Zhang Yong Y Grigoryan Vardui V Feng Tiantian T Thayer Julian F JF Lehrer Paul P Chang Catie C Stanley Jeffrey A JA Head Elizabeth E Rouanet Jeremy J Marmarelis Vasilis Z VZ Narayanan Shrikanth S Wisnowski Jessica J Nation Daniel A DA Mather Mara M

Scientific data 20230729 1

We present data from the Heart Rate Variability and Emotion Regulation (HRV-ER) randomized clinical trial testing effects of HRV biofeedback. Younger (N = 121) and older (N = 72) participants completed baseline magnetic resonance imaging (MRI) including T<sub>1</sub>-weighted, resting and emotion regulation task functional MRI (fMRI), pulsed continuous arterial spin labeling (PCASL), and proton magnetic resonance spectroscopy (<sup>1</sup>H MRS). During fMRI scans, physiological measures (blood ...[more]

PMID: 37516756

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Project description:Despite previous findings of therapeutic effects for heart rate variability biofeedback (HRVB) on asthma, it is not known whether HRVB can substitute either for controller or rescue medication, or whether it affects airway inflammation. Sixty-eight paid volunteer steroid naïve study participants with mild or moderate asthma were given 3 months of HRVB or a comparison condition consisting of EEG alpha biofeedback with relaxing music and relaxed paced breathing (EEG+), in a two-center trial. All participants received a month of intensive asthma education prior to randomization. Both treatment conditions produced similar significant improvements on the methacholine challenge test (MCT), asthma symptoms, and asthma quality of life (AQOL). MCT effects were of similar size to those of enhanced placebo procedures reported elsewhere, and were 65% of those of a course of a high-potency inhaled steroid budesonide given to a sub-group of participants following biofeedback training. Exhaled nitric oxide decreased significantly only in the HRVB group, 81% of the budesonide effect, but with no significant differences between groups. Participants reported becoming more relaxed during practice of both techniques. Administration of albuterol after biofeedback sessions produced a large improvement in pulmonary function test results, indicating that neither treatment normalized pulmonary function as a potent controller medication would have done. Impulse oscillometry showed increased upper airway (vocal cord) resistance during biofeedback periods in both groups. These data suggest that HRVB should not be considered an alternative to asthma controller medications (e.g., inhaled steroids), although both biofeedback conditions produced some beneficial effects, warranting further research, and suggesting potential complementary effects. Various hypotheses are presented to explain why HRVB effects on asthma appeared smaller in this study than in earlier studies. Clinical Trial Registration NCT02766374.

Dataset Information

Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial.

Publications

Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial.

Similar Datasets

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