Changes in equine intestinal stem/progenitor cell number at resection margins in cases of small intestinal strangulation.

ABSTRACT:

Background

Intestinal epithelial stem cells (ISC) are responsible for epithelial regeneration and are critical to the intestine's ability to regain barrier function following injury. Evaluating ISC biomarker expression in cases of small intestinal strangulation (SIS) may provide insight into clinical progression.

Objectives

Intestinal resection margins from cases of SIS were evaluated to determine if (1) evidence of injury could be identified using histomorphometry, (2) ISC biomarker expression was decreased in the proximal resection margin compared to control and distal resection margin, and (3) the ISC biomarker expression was associated with the number of preoperative risk factors negatively related to outcome, post-operative complications, or case outcome.

Study desig

SUBMITTER: Veerasammy B 

PROVIDER: S-EPMC10387127 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature