Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction.

ABSTRACT:

Objective

To use genome-wide association study (GWAS) by subtraction, a method for deriving novel GWASs from existing summary statistics, to derive genome-wide summary statistics for paternal smoking.

Result

A GWAS by subtraction was implemented using a weighted linear model that defined the child-genotype paternal-phenotype association as the child-genotype child-phenotype association minus the child-genotype maternal-phenotype association. We first use the laws of inherence to derive the weighted linear model. We then implemented the linear model to create a GWAS of paternal smoking by subtracting the summary statistics from a GWAS of maternal smoking from the summary statistics of a GWAS of the index individual's smoking. We used a Monte-Carlo simulation to validate the m

SUBMITTER: Woolf B 

PROVIDER: S-EPMC10387204 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature