Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation.

ABSTRACT: Cancer cachexia is a multifactorial syndrome of body weight loss, muscle wasting and progressive functional decline, affecting many advanced cancer patients and leading to worsened clinical outcomes. Despite inherent limitations of many preclinical cachexia models, including large tumor burden, rapid tumor growth and young age of animals, these animal models are widely used and imperative for the study of cachexia mechanisms and experimental therapeutics. However, there are currently no guidelines for the reporting and representation of data in preclinical cachexia literature. We examined the current state of data reporting in publications using the colon-26 adenocarcinoma (C26) model of cachexia and compared statistical differences in reporting mechanisms using animals from our laboratory

SUBMITTER: Beaudry AG 

PROVIDER: S-EPMC10387346 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature