A single centre in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure.

ABSTRACT:

Background

High numbers of unknown classifications and inconsistent methodologies in previous studies make the interpretation of causes leading to graft loss difficult. In addition, data on a holistic view looking at both death with a functioning graft (DWFG) and death-censored graft failure (DCGF) are sparse.

Methods

In this single-centre study we included 1477 adult kidney transplants performed between 1997 and 2017, of which all 286 DWFGs until the end of observation were analysed and causes for death assigned. Additionally, the results were compared with the causes of 303 DCGFs of the same cohort to evaluate the impact of causes for overall graft loss.

Results

The most frequent causes for DWFG were cardiovascular disease (CVD) in 30.8%, malignancy in 28.3% and inf

SUBMITTER: Mayrdorfer M 

PROVIDER: S-EPMC10387383 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature