Pharmacological strategies to manage hyperkalaemia: out with the old, in with the new? Not so fast….

ABSTRACT: Since the 1950s, sodium polystyrene sulphonate (SPS) has been the dominant cation exchange agent prescribed for hyperkalaemia. Clinicians have had plenty of time to learn of SPS's advantages and limitations. The demands of drug regulatory agencies regarding the incorporation of medications into the market were not so stringent then as they are today, and the efficacy and safety of SPS have been questioned. In recent years, two novel cation exchangers, patiromer and sodium zirconium cyclosilicate, have received (or are in the process of receiving) regulatory approval in multiple jurisdictions globally, after scrutiny of carefully conducted trials regarding their short-term and mid-term efficacy. In this debate, we defend the view that all three agents are likely to have similar efficacy. Ha

SUBMITTER: Carrero JJ 

PROVIDER: S-EPMC10387386 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature