Dietary lithium intake, graft failure and mortality in kidney transplant recipients.

ABSTRACT:

Background

Long-term high-dose lithium therapy in bipolar disorder is known to adversely affect kidney function. However, recent animal studies have revealed that low amounts of lithium are beneficial for the kidney when it is damaged by exposure to nephrotoxic compounds, inflammation or oxidative stress. This study aimed to investigate whether urinary lithium excretion, reflecting dietary lithium intake, is associated with adverse long-term kidney graft outcomes and patient survival.

Methods

Urinary lithium concentration was measured using inductively coupled plasma mass spectrometry in 642 stable kidney transplant recipients (KTRs). Graft failure was defined as the start of dialysis or retransplantation and kidney function decline was defined as a doubling of serum creatin

SUBMITTER: Post A 

PROVIDER: S-EPMC10387402 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature