Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity.

ABSTRACT: T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to disease. Here, we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes, as well as dynamic alterations. After restricting the N-glycosylation profile of thymocytes to high-mannose structures, using specific glycoengineered mice (Rag1^CreMgat1^fl/fl), we s

SUBMITTER: Vicente MM 

PROVIDER: S-EPMC10387478 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature