Ontology highlight
ABSTRACT:
SUBMITTER: Vicente MM
PROVIDER: S-EPMC10387478 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Vicente Manuel M MM Alves Inês I Fernandes Ângela  Dias Ana M AM Santos-Pereira Beatriz B Pérez-Anton Elena E Santos Sofia S Yang Tao T Correia Alexandra A Münster-Kühnel Anja A Almeida Afonso R M ARM Ravens Sarina S Rabinovich Gabriel A GA Vilanova Manuel M Sousa Ana E AE Pinho Salomé S SS
Cellular & molecular immunology 20230621 8
T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to disease. Here, we discover ...[more]