Peanut butter feeding induces oral tolerance in genetically diverse collaborative cross mice.

ABSTRACT:

Background

Early dietary introduction of peanut has shown efficacy in clinical trials and driven pediatric recommendations for early introduction of peanut to children with heightened allergy risk worldwide. Unfortunately, tolerance is not induced in every case, and a subset of patients are allergic prior to introduction. Here we assess peanut allergic sensitization and oral tolerance in genetically diverse mouse strains.

Objective

We aimed to determine whether environmental adjuvant-driven airway sensitization and oral tolerance to peanut could be induced in various genetically diverse mouse strains.

Methods

C57BL/6J and 12 Collaborative Cross (CC) mouse strains were fed regular chow or ad libitum peanut butter to induce tolerance. Tolerance was tested by atte

SUBMITTER: Immormino RM 

PROVIDER: S-EPMC10387557 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature