Blood pressure medication and acute kidney injury after intracerebral haemorrhage: an analysis of the ATACH-II trial.

ABSTRACT:

Background

Acute blood pressure (BP) reduction is standard of care after acute intracerebral haemorrhage (ICH). More acute BP reduction is associated with acute kidney injury (AKI). It is not known if the choice of antihypertensive medications affects the risk of AKI.

Methods

We analysed data from the ATACH-II clinical trial. AKI was defined by the Kidney Disease: Improving Global Outcomes criteria. We analysed antihypertensive medication from two sources. The first was a case report form that specified the use of labetalol, diltiazem, urapidil or other. We tested the hypothesis that the secondary medication was associated with AKI with χ² test. Second, we tested the hypotheses the dosage of diltiazem was associated with AKI using Mann-Whitney U test.

Results</

SUBMITTER: Naidech AM 

PROVIDER: S-EPMC10387642 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature