New pyrimidine-N-β-D-glucosides: synthesis, biological evaluation, and molecular docking investigations.

ABSTRACT: In this study, syntheses of new pyrimidine-coupled N-β-glucosides and tetra-O-acetyl derivatives were carried out. All glycoconjugates were investigated in comparison with known chemotherapeutic agents in terms of their antimicrobial and anticancer functions and DNA/protein binding affinities. Spectral data showed that all glycoside derivatives were obtained by diastereoselectivity as β-anomers. Both tested groups exhibited strong antiproliferative activity (2.29-66.84 μg/mL), but some of them had sufficiently ideal % cytotoxicity values (10.01%-16.78%). And also all synthetic compounds exhibited remarkable antibacterial activity against human pathogenic bacteria. Binding of these compounds to CT-DNA resulted in significant changes in spectral properties, consistent with groo

SUBMITTER: Kahriman N 

PROVIDER: S-EPMC10387993 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature