Antiadipogenic and antiobesogenic effects of pterostilbene in 3T3-L1 preadipocyte models.

ABSTRACT: Since obesity causes at least 2.8 million death each year and is a major risk factor for many diseases, it is critical to evaluate alternative treatment approaches. In this context, studies on the research of natural product-based therapeutics in the fight against obesity are increasing. In this study, it was aimed to evaluate the antiadipogenic and antiobesogenic efficacy of pterostilbene a natural phenolic compound in 3T3-L1 cells. The mature 3T3-L1 adipocytes were exposed to pterostilbene at different concentrations and half-maximum inhibitory concentrations (IC₅₀) were determined by MTT assay. Oil-Red-O staining was applied to determine lipid accumulation. Phase contrast microscopy, Giemsa, F-actin and DAPI staining were applied to examine the efficacy of pterostilbene on th

SUBMITTER: Gulnar B 

PROVIDER: S-EPMC10388082 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature