Stable and exacerbation period serum cytokine and periostin levels of the five distinct phenotypes of severe asthma.

ABSTRACT:

Background

The differences in molecular mechanisms during a stable period and the changes in the inflammatory responses during exacerbations between distinct severe asthma phenotypes remain unclear. In this study, we aimed to characterize stable and exacerbation period serum cytokine and periostin levels of 5 different predefined severe asthma phenotypes with real-life data. Changes in the viral infection-induced exacerbations were also analyzed.

Methods

Serum levels of 8 cytokines and periostin were measured from the sera obtained from the adult patients with five different severe asthma phenotypes based on the presence/absence of aeroallergen sensitivity, peripheral eosinophilia and chronic rhinosinusitis with nasal polyposis (CRSwNP) during stable and exacerbation periods

SUBMITTER: Turk M 

PROVIDER: S-EPMC10388125 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature