Hydrogen peroxide-induced oxidative damage and protective role of peroxiredoxin 6 protein via EGFR/ERK signaling pathway in RPE cells.

ABSTRACT:

Introduction

Damage to retinal pigment epithelium (RPE) cells caused by oxidative stress is closely related to the pathogenesis of several blinding retinal diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa, and other inherited retinal degenerative conditions. However, the mechanisms of this process are poorly understood. Hence, the goal of this study was to investigate hydrogen peroxide (H₂O₂)-induced oxidative damage and protective role of peroxiredoxin 6 (PRDX6) protein via EGFR/ERK signaling pathway in RPE cells.

Methods

Cells from a human RPE cell line (ARPE-19 cells) were treated with H₂O₂, and then cell viability was assessed using the methyl thiazolyl tetrazolium assay. Cell death and reactive ox

SUBMITTER: Chen X 

PROVIDER: S-EPMC10388243 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature