Sustained specialized and family treatment in first-episode schizophrenia or related disorders: a 5-year randomized controlled trial.

ABSTRACT:

Background

The long-term outcome of first-episode schizophrenia needs improvement. Here, we evaluate the effectiveness of 5 years sustained specialist treatment (ST), ST including Parent groups (ST + P) or treatment as usual (TAU) on psychotic relapse and social functioning.

Methods

A three condition randomized, parallel assigned, single-blind efficacy trial, in which 198 first-episode psychosis (FEP) patients aged 15-28 years were included. The effect on time to first relapse, first relapse rates, mean number of relapses per patient, and time to the improvement of social functioning were analyzed using Cox regression or ANOVA.

Results

We found no significant differences between treatment conditions in the ITT analysis concerning time to first relapse, nor first relap

SUBMITTER: de Haan L 

PROVIDER: S-EPMC10388306 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature