Acute neural effects of fluoxetine on emotional regulation in depressed adolescents.

ABSTRACT:

Background

Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate the neural mechanisms underlying these key processes. The current study therefore investigated the neural effects of fluoxetine on emotional reactivity and cognitive reappraisal in adolescent depression.

Methods

Thirty-one adolescents with MDD were randomised to acute fluoxetine (10 mg) or placebo. Seventeen healthy adolescents were also recruited but did not receive any treatment for ethical reasons. During functional magnetic resonance imaging (fMRI), participants viewed aversive images and were asked to either experience naturally the emotion

SUBMITTER: Capitao LP 

PROVIDER: S-EPMC10388313 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature