Reduced fractional anisotropy in bipolar disorder v. major depressive disorder independent of current symptoms.

ABSTRACT:

Background

Patients with bipolar disorder (BD) show reduced fractional anisotropy (FA) compared to patients with major depressive disorder (MDD). Little is known about whether these differences are mood state-independent or influenced by acute symptom severity. Therefore, the aim of this study was (1) to replicate abnormalities in white matter microstructure in BD v. MDD and (2) to investigate whether these vary across depressed, euthymic, and manic mood.

Methods

In this cross-sectional diffusion tensor imaging study, n = 136 patients with BD were compared to age- and sex-matched MDD patients and healthy controls (HC) (n = 136 each). Differences in FA were investigated using tract-based spatial statistics. Using interaction models, the influence of acute

SUBMITTER: Thiel K 

PROVIDER: S-EPMC10388324 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature