Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode.

ABSTRACT:

Background

Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering the polygenic nature of these complex phenotypes are required to unravel the mechanisms underlying the early progression of the disorder.

Methods

The sample comprised of 233 first-episode psychosis (FEP) subjects with clinical and cognitive data assessed periodically for a 2-year period and 150 matched controls. Polygenic risk scores (PRSs) for schizophrenia, bipolar disorder, depression, education attainment and cognitive performance were used to assess the genetic risk of FEP and to characterize their association w

SUBMITTER: Segura AG 

PROVIDER: S-EPMC10388335 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature