Synthesis of natural polyprenols for the production of biological prenylquinones and tocochromanols.

ABSTRACT: We elaborate the chemical synthesis of polyprenols by chain lengthening, which is considerably less time-consuming than the other previously described methods. Our method eliminates critical steps requiring low temperature and toxic chemicals, which are difficult to perform in ordinary laboratories. The critical step of acetylene addition in liquid ammonia was replaced by a new approach, namely, the use of sodium acetylide in dimethoxyethane at room temperature, where the reaction is completed within one hour. This method is of general significance as it can also be applied to the synthesis of any other acetylides. Our method provides reasonable yields and can be scaled depending on the requirements. All the reactions were followed by high-performance liquid chromatography, allowing the fo

SUBMITTER: Kruk J 

PROVIDER: S-EPMC10388336 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature