Targeting EP2 Receptor for Drug Discovery: Strengths, Weaknesses, Opportunities, and Threats (SWOT) Analysis.
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ABSTRACT:
SUBMITTER: Ganesh T
PROVIDER: S-EPMC10388357 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
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Targeting EP2 Receptor for Drug Discovery: Strengths, Weaknesses, Opportunities, and Threats (SWOT) Analysis.
Journal of medicinal chemistry 20230717 14
Cyclooxygenase-1 and -2 (COX1 and COX2) derived endogenous ligand prostaglandin-E<sub>2</sub> (PGE<sub>2</sub>) triggers several physiological and pathological conditions. It mediates signaling through four G-protein coupled receptors, EP1, EP2, EP3, and EP4. Among these, EP2 is expressed throughout the body including the brain and uterus. The functional role of EP2 has been extensively studied using EP2 gene knockout mice, cellular models, and selective small molecule agonists and antagonists f ...[more]
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