Targeting EP2 Receptor for Drug Discovery: Strengths, Weaknesses, Opportunities, and Threats (SWOT) Analysis.

ABSTRACT: Cyclooxygenase-1 and -2 (COX1 and COX2) derived endogenous ligand prostaglandin-E₂ (PGE₂) triggers several physiological and pathological conditions. It mediates signaling through four G-protein coupled receptors, EP1, EP2, EP3, and EP4. Among these, EP2 is expressed throughout the body including the brain and uterus. The functional role of EP2 has been extensively studied using EP2 gene knockout mice, cellular models, and selective small molecule agonists and antagonists for this receptor. The efficacy data from in vitro and in vivo animal models indicate that EP2 receptor is a major proinflammatory mediator with deleterious functions in a variety of diseases suggesting a path forward for EP2 inhibitors as the next generation of selective anti-inflammatory and antipr

SUBMITTER: Ganesh T 

PROVIDER: S-EPMC10388357 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature