Enantioselective transition-metal catalysis via an anion-binding approach.

ABSTRACT: Asymmetric transition-metal catalysis represents a powerful strategy for accessing enantiomerically enriched molecules^1-3. The classical strategy for inducing enantioselectivity with transition-metal catalysts relies on direct complexation of chiral ligands to produce a sterically constrained reactive metal site that allows formation of the major product enantiomer while effectively inhibiting the pathway to the minor enantiomer through steric repulsion⁴. The chiral-ligand strategy has proven applicable to a wide variety of highly enantioselective transition-metal-catalysed reactions, but important scenarios exist that impose limits to its successful adaptation. Here, we report a new approach for inducing enantioselectivity in transition-metal-catalysed reactions that

SUBMITTER: Ovian JM 

PROVIDER: S-EPMC10388379 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature