Activation of the Mu-Delta Opioid Receptor Heteromers Blocks Morphine Rewarding Effects.

ABSTRACT:

Background

Evidence has accumulated demonstrating the existence of opioid receptor heteromers, and recent data suggest that targeting these heteromers could reduce opioid side effects while retaining therapeutic effects. Indeed, CYM51010 characterized as a MOR (mu opioid receptor)/DOR (delta opioid receptor) heteromer-preferring agonist promoted antinociception comparable with morphine but with less tolerance. In the perspective of developing these new classes of pharmacological agents, data on their putative side effects are mandatory.

Methods

Therefore, in this study, we investigated the effects of CYM51010 in different models related to drug addiction in mice, including behavioral sensitization, conditioned place preference and withdrawal.

Results

We found that, li

SUBMITTER: Requana Aradas A 

PROVIDER: S-EPMC10388387 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature