Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications.

ABSTRACT:

Objective

The diversity of the tumour microenvironment (TME) of intrahepatic cholangiocarcinoma (iCCA) has not been comprehensively assessed. We aimed to generate a novel molecular iCCA classifier that incorporates elements of the stroma, tumour and immune microenvironment ('STIM' classification).

Design

We applied virtual deconvolution to transcriptomic data from ~900 iCCAs, enabling us to devise a novel classification by selecting for the most relevant TME components. Murine models were generated through hydrodynamic tail vein injection and compared with the human disease.

Results

iCCA is composed of five robust STIM classes encompassing both inflamed (35%) and non-inflamed profiles (65%). The inflamed classes, named immune classical (~10%) and inflammator

SUBMITTER: Martin-Serrano MA 

PROVIDER: S-EPMC10388405 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature