Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.

ABSTRACT:

Background

Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted to AD with those who remained with a stable aMCI diagnosis during the follow-up.

Methods

Four hund

SUBMITTER: Tuena C 

PROVIDER: S-EPMC10388514 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature