Therapeutic response to pazopanib: case report and literature review on molecular abnormalities of aggressive prolactinomas.

ABSTRACT:

Introduction

Aggressive prolactinomas (APRLs) pose a significant clinical challenge due to their high rate of regrowth and potentially life-threatening complications. In this study, we present a case of a patient with an APRL who had a trial of multiple therapeutic modalities with the aim to provide a review of molecular abnormalities and management of APRLs by corroborating our experience with previous literature.

Methods

A total of 268 articles were reviewed and 46 were included. Case reports and series, and studies that investigated the molecular and/or genetic analysis of APRLs were included. Special care was taken to include studies describing prolactinomas that would fall under the APRL subtype according to the European Society of Endocrinology guidelines; however, the

SUBMITTER: Medina EJ 

PROVIDER: S-EPMC10388536 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature