Mass Spectrometry-Based Proteomics of Epithelial Ovarian Cancers: A Clinical Perspective.

ABSTRACT: Increasing proteomic studies focused on epithelial ovarian cancer (EOC) have attempted to identify early disease biomarkers, establish molecular stratification, and discover novel druggable targets. Here we review these recent studies from a clinical perspective. Multiple blood proteins have been used clinically as diagnostic markers. The ROMA test integrates CA125 and HE4, while the OVA1 and OVA2 tests analyze multiple proteins identified by proteomics. Targeted proteomics has been widely used to identify and validate potential diagnostic biomarkers in EOCs, but none has yet been approved for clinical adoption. Discovery of proteomic characterization of bulk EOC tissue specimens has uncovered a large number of dysregulated proteins, proposed new stratification schemes, and revealed novel

SUBMITTER: Qian L 

PROVIDER: S-EPMC10388592 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature