Metabolomic profile of patients on levothyroxine treatment for hypothyroidism.

ABSTRACT:

Background

Hypothyroidism is clinically characterized by a decrease in levels of the circulating thyroid hormones namely thyroxine and triiodothyronine. The main treatment for hypothyroidism is thyroid hormone replacement using levothyroxine to normalize serum thyroid hormone levels.

Objectives

In this study, we explored the metabolic changes in the plasma of patients with hypothyroidism after reaching a euthyroid state with levothyroxine treatment.

Methods

Plasma samples from 18 patients diagnosed as overt hypothyroidism were collected before and after levothyroxine treatment upon reaching a euthyroid state and were analyzed by high-resolution mass spectrometry-based metabolomics. Multivariate and univariate analyses evaluated data to highlight potential metabolic bi

SUBMITTER: Benabdelkamel H 

PROVIDER: S-EPMC10388654 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature