Elevated serum trimethylamine oxide levels as potential biomarker for diabetic kidney disease.

ABSTRACT:

Background

Diabetic kidney disease (DKD) has become a major cause of chronic kidney disease. However, early diagnosis of DKD is challenging. Trimethylamine oxide (TMAO) is an intestinal microbial metabolite which might be associated with diabetes complications. The aim of this study was to investigate the correlation between TMAO and DKD.

Methods

A cross-sectional study was conducted. A total of 108 T2DM patients and 33 healthy subjects were enrolled in this study. Multiple logistic regression analyses and area under receiver operating characteristic curves (AUROC) were performed to evaluate the correlation between serum TMAO and DKD.

Results

Serum TMAO levels were significantly higher in DKD patients than healthy control group and the NDKD (T2DM without combined DKD)

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10388659 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature