Optimising prednisolone or prednisone replacement in adrenal insufficiency.

ABSTRACT:

Context

Patients with adrenal insufficiency (AI) have a higher mortality than the general population, possibly because of excess glucocorticoid exposure at inappropriate times. The cortisol circadian rhythm is difficult to mimic with twice- or thrice-daily hydrocortisone. Prednisolone is a once-daily alternative which may improve patient compliance through its convenience.

Objectives

Prednisolone day curves can be used to accurately downtitrate patients to the minimum effective dose. This study aimed to review prednisolone day curves and determine therapeutic ranges at different time points after administration.

Methods

Between August 2013 and May 2021, 108 prednisolone day curves from 76 individuals receiving prednisolone replacement were analysed. Prednisolone conce

SUBMITTER: Sharma A 

PROVIDER: S-EPMC10388668 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature