A systematic review of transcriptomic studies of the human endometrium reveals inconsistently reported differentially expressed genes.

ABSTRACT: Genome-wide analysis of gene expression has been widely applied to study the endometrium, although to our knowledge no systematic reviews have been performed. Here, we identified 74 studies that described transcriptomes from whole (unprocessed) endometrium samples and found that these fitted into three broad investigative categories; endometrium across the menstrual cycle, endometrium in pathology, and endometrium during hormone treatment. Notably, key participant information such as menstrual cycle length and body mass index was often not reported. Fertility status was frequently not defined and fertility-related pathologies, such as recurrent implantation failure (RIF) and recurrent pregnancy loss, were variably defined, while hormone treatments differed between almost every study. A ran

SUBMITTER: Walker ER 

PROVIDER: S-EPMC10388686 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature