Characterizing the Immune Microenvironment and Neoantigen Landscape of Hurthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities.

ABSTRACT: Hürthle cell carcinoma (HCC) is a rare type of thyroid cancer with high rates of distant metastasis and recurrence. Along with the scarcity of effective systemic therapies for HCC, these factors contribute to poor clinical outcomes. The immunologic features of HCC are poorly defined and response rates with immune checkpoint blockade have not been reported. A more comprehensive understanding of the immune landscape and factors that predict response to checkpoint inhibitors is needed. We performed RNA sequencing on 40 tumors to characterize the neoantigen landscape and immune microenvironment of HCC. We analyzed transcriptomic profiles, tumor-infiltrating immune cell populations, and measures of T-cell activation/dysfunction and correlated these to genetic features such as tumor mutation bur

SUBMITTER: Ganly I 

PROVIDER: S-EPMC10389111 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature