Kinetically Inert Macrocyclic Europium(III) Receptors for Phosphate.

ABSTRACT: The significant role that phosphate plays in environmental water pollution and biomedical conditions such as hyperphosphatemia highlights the need to develop robust receptors that can sequester the anion effectively and selectively from complex aqueous media. Toward that goal, four macrocyclic tris-bidentate 1,2-hydroxypyridonate (HOPO) europium(III) complexes containing either a cyclen, cyclam, TACN, or TACD ligand cap were synthesized and evaluated as phosphate receptors. The solubility of Eu^III-TACD-HOPO in water was insufficient for luminescent studies. Whereas Eu^III-cyclen-HOPO is eight coordinate with two inner-sphere water molecules, both Eu^III-cyclam-HOPO and Eu^III-TACN-HOPO are nine coordinate with three inner-sphere water molecules, sug

SUBMITTER: Martinon TLM 

PROVIDER: S-EPMC10389169 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature