Effects of Molecular Size on Resolution in Charge Detection Mass Spectrometry.

ABSTRACT: Instrumental resolution of Fourier transform-charge detection mass spectrometry instruments with electrostatic ion trap detection of individual ions depends on the precision with which ion energy is determined. Energy can be selected using ion optic filters or from harmonic amplitude ratios (HARs) that provide Fellgett's advantage and eliminate the necessity of ion transmission loss to improve resolution. Unlike the ion energy-filtering method, the resolution of the HAR method increases with charge (improved S/N) and thus with mass. An analysis of the HAR method with current instrumentation indicates that higher resolution can be obtained with the HAR method than the best resolution demonstrated for instruments with energy-selective optics for ions in the low MDa range and ab

SUBMITTER: Harper CC 

PROVIDER: S-EPMC10389281 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature