Application and development of noninvasive biomarkers for colorectal cancer screening: a systematic review.

ABSTRACT:

Background

Colorectal cancer (CRC) is the second most common cause of cancer-related death (9.4% of the 9.9 million cancer deaths). However, CRC develops slowly, and early detection and intervention can effectively improve the survival rate and quality of life. Although colonoscopy can detect and diagnose CRC, it is unsuitable for CRC screening in average-risk populations. Some commercial kits based on DNA mutation or methylation are approved for screening, but the low sensitivity for advanced adenoma or early-stage CRC would limit the applications.

Main results

Recently, researchers have focused on developing noninvasive or minimally invasive, easily accessible biomarkers with higher sensitivity and accuracy for CRC screening. Numerous reports describe advances in biomarker

SUBMITTER: Song D 

PROVIDER: S-EPMC10389553 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature