Impact of Microdevice Geometry on Transit and Retention in the Murine Gastrointestinal Tract.

ABSTRACT: Oral protein delivery technologies often depend on encapsulating or enclosing the protein cargo to protect it against pH-driven degradation in the stomach or enzymatic digestion in the small intestine. An emergent methodology is to encapsulate therapeutics in microscale, asymmetric, planar microparticles, referred to as microdevices. Previous work has shown that, compared to spherical particles, planar microdevices have longer residence times in the GI tract, but it remains unclear how specific design choices (e.g., material selection, particle diameter) impact microdevice behavior in vivo. Recent advances in microdevice fabrication through picoliter printing have expanded the range of device sizes that can be fabricated in a rapid manner. However, relatively little work has explored how d

SUBMITTER: Lykins WR 

PROVIDER: S-EPMC10389692 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature