Metabolic Control of Germline Formation and Differentiation in Mammals.

ABSTRACT:

Background

The germ cell lineage involves dynamic epigenetic changes during its formation and differentiation that are completely different from those of the somatic cell lineage. Metabolites and metabolic pathways have been reported as key factors related to the regulation of epigenetics as cofactors and substrates. However, our knowledge about the metabolic characteristics of germ cells, especially during the fetal stage, and their transition during differentiation is quite limited due to the rarity of the cells. Nevertheless, recent developments in omics technologies have made it possible to extract comprehensive metabolomic features of germ cells.

Summary

In this review, we present the latest researches on the metabolic properties of germ cells in 4 stages: primordial ge

SUBMITTER: Hayashi Y 

PROVIDER: S-EPMC10389803 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature