Artificial intelligence and bioinformatics analyze markers of children's transcriptional genome to predict autism spectrum disorder.

ABSTRACT:

Introduction

Autism spectrum disorder (ASD), characterized by difficulties in social interaction and communication as well as restricted interests and repetitive behaviors, is extremely challenging to diagnose in toddlers. Early diagnosis and intervention are crucial however.

Methods

In this study, we developed a machine learning classification model based on mRNA expression data from the peripheral blood of 128 toddlers with ASD and 126 controls. Differentially expressed genes (DEGs) between ASD and controls were identified.

Results

We identified genes such as UBE4B, SPATA2 and RBM3 as DEGs, mainly involved in immune-related pathways. 21 genes were screened as key biomarkers using LASSO regression, yielding an accuracy of 86%. A neural network model based on these 21

SUBMITTER: Tang H 

PROVIDER: S-EPMC10390071 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature