Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products.

ABSTRACT: The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid (1) and 2-(2,6-dibromo-3,5-dihydroxyphenyl)acetic acid (2) and as well as their derivatives 25 and 26 were carried out by substitution, hydrolysis and demethylation reactions of the corresponding four benzyl bromides. The antioxidant potentials of benzylic acid-derived bromophenols were, for the first time, appraised by several outstanding bioanalytical methods. Besides these, we estimated the antioxidant effects which were studied using the methods of DPPH·, ABTS^•+ scavenging activities, ferric (Fe³⁺) and cupric (Cu²⁺) ions and Fe³⁺-TPTZ reducing capacities. Benzylic acid-derived bromophenols were found as effective DPPH^•, and

SUBMITTER: Bayrak C 

PROVIDER: S-EPMC10390195 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature