Apparent treatment-resistant hypertension associated lifetime cardiovascular risk in a longitudinal national registry.

ABSTRACT:

Aims

Apparent treatment-resistant hypertension (aRH), wherein blood pressure elevation requires treatment with multiple medications, is associated with adverse cardiovascular events over the short-term. We sought to evaluate the degree of excess risk associated with aRH across the lifespan.

Methods and results

We identified all individuals with hypertension who were prescribed at least one anti-hypertensive medication from the FinnGen Study, a cohort of randomly selected individuals across Finland. We then identified the maximum number of concurrently prescribed anti-hypertensive medication classes prior to age 55 and classified those co-prescribed ≥4 anti-hypertensive medication classes as aRH. Using multivariable adjusted Cox proportional hazards models, we assessed the as

SUBMITTER: Ebinger JE 

PROVIDER: S-EPMC10390234 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature