Kidney function and cardiovascular diseases: a large-scale observational and Mendelian randomization study.

ABSTRACT:

Background

Prior observational studies have found an association between kidney function and cardiovascular diseases (CVDs). However, these studies did not investigate causality. Therefore, the aim of this study is to examine the causal relationship between kidney function and CVDs.

Methods

We utilized data from the eICU Collaborative Research Database (eICU-CRD) from the years 2014-2015 to evaluate the observational association between renal failure (RF) and CVDs. To investigate the causal effects of kidney function (estimated glomerular filtration rate [eGFR] and chronic kidney disease [CKD]) and CVDs (including atrial fibrillation [AF], coronary artery disease [CAD], heart failure [HF], any stroke [AS], and any ischemic stroke [AIS]), we conducted a two-sample bidirection

SUBMITTER: Hu C 

PROVIDER: S-EPMC10390297 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature