Dietary intervention reprograms bone marrow cellular signaling in obese mice.

ABSTRACT:

Objectives

The current study aimed to investigate the pathogenesis of obesity-induced impaired bone mass accrual and the impact of dietary intervention on bone density in the mouse model of obesity.

Methods

Mice were fed with chow diet (CD) for 10 months, high-fat-diet (HFD) for 10 months, or HFD for 6 months then transferred to chow diet for 4 months (HFDt).

Results

Weight loss and decreased intrahepatic lipid accumulation were observed in mice following dietary intervention. Additionally, HFD feeding induced bone mass accrual, while diet intervention restrained trabecular bone density. These changes were further reflected by increased osteogenesis and decreased adipogenesis in HFDt mice compared to HFD mice. Furthermore, HFD feeding decreased the activity of the Win

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10390309 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature