Effects of condensates from volcanic fumaroles and cigarette smoke extracts on airway epithelial cells.

ABSTRACT: The impact of volcanic airborne products on airway epithelium homeostasis is largely unknown. This study assessed the effects of volcanic Fumarole Condensates (FC) alone or combined with Cigarette Smoke Extracts (CSE) on airway epithelial cells (16HBE and A549). Chemical composition of FC was analyzed by gas chromatography and HPLC. Cells were exposed to FC and IL-33 and IL-8 were assessed. The effects of FC and CSE on cell injury were evaluated assessing cell metabolism/cell viability, mitochondrial stress, cell apoptosis/cell necrosis, and cell proliferation. FC contained: water vapor (70-97%), CO₂ (3-30%), acid gases (H₂S, SO₂, HCl, HF) around 1%. FC increased the intracellular IL-33 but differently modulated IL-33 and IL-8 gene expression and IL-8 relea

SUBMITTER: Di Sano C 

PROVIDER: S-EPMC10390407 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature