The therapeutic targets of N6-methyladenosine (m6A) modifications on tumor radioresistance.

ABSTRACT: Radiation therapy is an important tool for malignant tumors, and its tolerance needs to be addressed. In recent years, several studies have shown that regulators of aberrant m6A methylation play an important role in the formation, development and invasion and metastasis of tumors. A large number of studies have confirmed aberrant m6A methylation as a new target for tumour therapy, but research on whether it can play a role in tumor sensitivity to radiotherapy has not been extensive and thorough enough. Recent studies have shown that all three major enzymes of m6A methylation have significant roles in radioresistance, and that the enzymes that play a role differ in different tumor types and by different mechanisms, including regulating tumor cell stemness, affecting DNA damage and repair, a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10390431 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature