Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood.

ABSTRACT:

Background

Little is known about the relationship between early life body size and occurrence of life-course multiple chronic diseases (multimorbidity). We aim to evaluate associations of birth weight, childhood body size, and their changes with the risks of chronic diseases and multimorbidity.

Methods

This prospective cohort study included 246,495 UK Biobank participants (aged 40-69 years) who reported birth weight and childhood body size at 10 years old. Birth weight was categorized into low, normal, and high; childhood body size was reported as being thinner, average, or plumper. Multimorbidity was defined as having two or more of 38 chronic conditions retrieved from inpatient hospital data until 31 December, 2020. The Cox regression and quasi-Poisson mixed effects models

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10390459 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature