N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice.

ABSTRACT: The endocannabinoid system (ECS) plays a key modulatory role during synaptic plasticity and homeostatic processes in the brain and has an important role in the neurobiological processes underlying drug addiction. We have previously shown that an elevated ECS response to psychostimulant (cocaine) is involved in regulating the development and expression of cocaine-conditioned reward and sensitization. We therefore hypothesized that drug-induced elevation in endocannabinoids (eCBs) and/or eCB-like molecules (eCB-Ls) may represent a protective mechanism against drug insult, and boosting their levels exogenously may strengthen their neuroprotective effects. Here, we determine the involvement of ECS in alcohol addiction. We first measured the eCBs and eCB-Ls levels in different brain reward syst

SUBMITTER: Shahen-Zoabi S 

PROVIDER: S-EPMC10390512 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature