A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion.

ABSTRACT: T cells play a key role in a variety of immune responses, including infection and cancer. Upon stimulation, naïve CD8+ T cells proliferate and differentiate into a variety of memory and effector cell types; however, failure to clear antigens causes prolonged stimulation of CD8+ T cells, ultimately leading to T cell exhaustion (TCE). The functional and phenotypic changes that occur during CD8+ T cell differentiation are well characterized, but the underlying gene expression state changes are not completely understood. Here, we utilize a previously published data-driven Boolean model of gene regulatory interactions shown to mediate TCE. Our network analysis and modeling reveal the final gene expression states that correspond to TCE, along with the sequence of gene expression patterns that gi

SUBMITTER: Ildefonso GV 

PROVIDER: S-EPMC10390540 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature