Reciprocal Interaction of Cancer Stem Cells of Cholangiocarcinoma with Macrophage.

ABSTRACT: Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. Therefore, there is great need to better understand the biology of this malignancy to further development of novel treatment options. Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. However, due to their elusive character and differences in identification among different types of cancer, it remains a challenge to study such cells. Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. Following verification of a stem-like signature (upregulated e

SUBMITTER: Wang X 

PROVIDER: S-EPMC10390592 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature