Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts.

ABSTRACT:

Aims/hypothesis

The euglycaemic-hyperinsulinaemic clamp (EIC) is the reference standard for the measurement of whole-body insulin sensitivity but is laborious and expensive to perform. We aimed to assess the incremental value of high-throughput plasma proteomic profiling in developing signatures correlating with the M value derived from the EIC.

Methods

We measured 828 proteins in the fasting plasma of 966 participants from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study and 745 participants from the Uppsala Longitudinal Study of Adult Men (ULSAM) using a high-throughput proximity extension assay. We used the least absolute shrinkage and selection operator (LASSO) approach using clinical variables and protein measures as features. Models

SUBMITTER: Zanetti D 

PROVIDER: S-EPMC10390625 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature